The intravenous (IV) and subcutaneous (SC) toxicity and absorption kinetics of the antileishmanial triterpene saponin PX-6518 and its active constituents maesabalide-III and -IV were studied in mice and dogs.A high-dose wash-out study of PX-6518 at 20 mg/kg SC for 5 days and a single low-dose wash-out study at 1, 2.5 or 5 mg/kg SC and IV with follo
The use of ultrasonography (US) as an imaging modality in medicine has spread across almost every clinical specialty.This diffusion is based on the simplicity, accessibility, portability and affordability of the technique producing real-time high-resolution images using non-ionising radiation.On the other hand, this trend also extended the techniqu
Preferential bus lanes are a widely use strategy to promote travelers to use public transport instead of private cars.Considering its relevance in the urban transportation planning and operation, it is crucial to evaluate them in terms of the operation and safety externality.We performed a road Shorts safety assessment in preferential public transp